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Recombinant EIF4EBP1 protein
| Aliases: Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1 |
| Catalog No: 81391 | Format: 50 µg | ¥3,760 | Add to Cart |
| Catalog No: 81691 | Format: 1 mg | ¥25,600 | Add to Cart |
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Expressed In: E. coli Protein Species: Human
Contents
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
Background
EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1 ) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Application Notes
This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data this product is shown.
Protein Details
Recombinant EIF4EBP1 protein was expressed in E.coli as the full length protein (accession number NP_004086.1) with an N-terminal 6×His tag. The molecular weight of the protein is 14.51 kDa.
References
Human
Recombinant EIF4EBP1 protein
12.5% SDS-PAGE Coomassie staining
M.W.: 14.51 kDa
Purity: ≥ 90%
Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Guarantee
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
