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Transcriptional Regulation and Cancer

Genetic and epigenetic modifications are fundamental to normal development and alterations in the regulation of gene expression have been reported in a wide range of diseases. The significance of epigenetic alterations in cancer is supported by the fact that they have been found in every tumor type studied to date, both benign and malignant. During tumor initiation and progression, gene regulation becomes altered by the aberrant genetic inactivation/activation of transcription factors and by changes to the epigenome, including a genome-wide loss of DNA methylation, frequent increases in promoter methylation of CpG islands, changes in nucleosome occupancy, and shifts in modification profiles.
Quantitate Transcription Factor activation
Transam Understanding and quantifying transcription factors is essential for the study of cell function in relation to differentiation, brain activity, immune response, inflammation and various disease states such as cancer. The TransAM® Kits are sensitive, non-radioactive transcription factor plate based assays that facilitate the study of transcription factor activation in mammalian tissue and cell extracts. Active Motif offers TransAM® assays for over 40 different targets. More >