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RapCap Beads have revolutionized the isolation of cell‐free DNA (cfDNA) from plasma and saliva by enabling a simplified, column‐free workflow. Unlike traditional spin-column methods that rely on multiple centrifugation and binding steps, RapCap Beads use a surface engineered for high affinity to cfDNA, allowing rapid and efficient capture directly from plasma, saliva, or other liquid biopsy samples.
RapCap™ Beads are magnetic beads with a novel DNA-binding affinity chemistry for cfDNA isolation that are not silica- or ion exchange-based technology. By using this unique approach, cfDNA can be efficiently concentrated from trace amounts in various samples and volume sizes, providing a scalable soultion for low-abundance nucleic acid recovery. The RapCap Beads system also eliminates the use of harsh chemical treatments or precipiation steps, enabling size-based discrimination of nucleic acids, offering unique versatility compared to existing methods of cfDNA isolation. This streamlined approach not only reduces processing time and manual handling but also minimizes genomic DNA contamination, ultimately enhancing the sensitivity and reproducibility of downstream analyses like PCR and next-generation sequencing.
5.5 ng of cfDNA isolated from 1 mL of plasma. 80% recovered as cfDNA. cfDNA defined as 50 bp to 700 bp.
RapCap™ Beads Advantages
- Simplified workflow
- 40% reduction in total assay time, >65% reduction in hands-on-time
- No ethanol, no drying - fully aqueous chemistry simplifies purification
- No additional spin needed for plasma samples after thawing - genomic DNA (gDNA) levels already low
- No protein carry-over (proteinase K digestion is not needed, no inhibitors present)
- Highly selective for cell free DNA (cfDNA)
- 90 to 99% reduction in contaminating gDNA for plasma samples
- 75% reduction in contaminating gDNA for saliva samples
- Versatile
- Purifies cfDNA from urine, saliva, plasma, and other complex starting solutions
- Equivalent DNA recovery from 100 µL to 10 mL
How RapCap™ Beads Work
RapCap™ Beads enable >80% recovery of ng quantities of cfDNA sized from dilute samples 100 µL to 10 mL sample volumes.
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Simplified cfDNA purification with rapid capture magnetic beads for cfDNA isolation from plasma samples.
Simplified workflow yielding cfDNA with exceptional purity. Rapid capture magnetic beads for cfDNA Isolation from saliva samples.
