Recombinant SETD4 protein

Aliases: SET Domain Containing Protein 4
Catalog No: 81280 Format: 20 µg ¥3,840 Add to Cart
Catalog No: 81980 Format: 1 mg ¥33,200 Add to Cart

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Expressed In: Baculovirus Protein Species: Human

Contents

A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.

Background

SETD4 (SET domain-containing protein 4), Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response. Regulates the inflammatory response by mediating mono and dimethylation of ‘Lys-4’ of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha. Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of ‘Lys-20’ of histone H4 (H4K20me3), thereby promoting heterochromatin formation. Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).

Application Notes

Recombinant SETD4 protein is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

Protein Details

Full length human SETD4 protein (accession number NP_059134.1) was expressed in baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of SETD4 is 51.7 kDa.

References

Human

 
Recombinant SETD4 protein

Recombinant SETD4 protein

10% SDS-PAGE with Coomassie blue staining

MW: 51.7 kDa

Purity: >90%

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.