Recombinant KDR / VEGFR2 (789-1356) protein

Aliases: VEGFR2, Flk-1
Catalog No: 81353 Format: 20 µg ¥3,840 Add to Cart
Catalog No: 81753 Format: 1 mg ¥33,200 Add to Cart

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Expressed In: Baculovirus Protein Species: Human

Contents

A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.

Background

KDR (Kinase Insert Domain Receptor) is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD and plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. KDR promotes proliferation, survival, migration and differentiation of endothelial cells and promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Diseases associated with KDR is infantile capillary hemangiomas.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product.  All available data this product is shown.

Protein Details

Recombinant KDR / VEGFR2 (789-1356) protein that includes amino acids 789-1356 of human KDR protein (accession number NP_002244.1) with a N-terminal FLAG tag. The molecular weight of the protein is 64.4 kDa.

 
Recombinant KDR / VEGFR2 (789-1356) protein gel

Recombinant KDR / VEGFR2 (789-1356) protein gel
10% SDS-PAGE with Coomassie staining
MW: 64.4 kDa
Purity: >90%

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.