Active Motif,
Tools to analyze nuclear function,
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表观遗传 & 染色质

Sirtuins (SIRT & Sir2)

epigenetic modulators of sirtuins

Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.

Active Motif offers several activators and inhibitors to study the effects of Sirtuins.

 
Name Appl. Format Cat No. Price  
AK-7 SIRT2 Inhibitor 25 mg 14054 ¥3,987.50 Buy Now
5 mg 14055 ¥1,160 Buy Now
BML-278 SIRT1 Activator 25 mg 14024 ¥4,277.50 Buy Now
5 mg 14025 ¥1,232.50 Buy Now
EX-527 SIRT1 Inhibitor 25 mg 14028 ¥4,857.50 Buy Now
5 mg 14029 ¥1,305 Buy Now
Piceatannol SIRT1 Activator 25 mg 14036 ¥3,480 Buy Now
5 mg 14037 ¥1,015 Buy Now
Resveratrol SIRT1 Activator 500 mg 14022 ¥3,480 Buy Now
100 mg 14023 ¥1,015 Buy Now
Salermide SIRT Inhibitor 25 mg 14124 ¥3,987.50 Buy Now
5 mg 14125 ¥1,522.50 Buy Now
SirtAct SIRT1 Activator 25 mg 14080 ¥9,715 Buy Now
5 mg 14081 ¥2,320 Buy Now
Sirtinol SIRT Inhibitor 25 mg 14074 ¥7,032.50 Buy Now
5 mg 14075 ¥1,740 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 ¥3,625 Buy Now
5 mg 14087 ¥1,015 Buy Now
Triacetyl resveratrol SIRT Activator 250 mg 14116 ¥5,075 Buy Now
50 mg 14117 ¥2,030 Buy Now