Splitomicin

Aliases: Splitomycin, 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Catalog No: 14086 Format: 25 mg ¥3,250 Buy
Catalog No: 14087 Format: 5 mg ¥850 Buy
Application: Sirtuins

Chemical Properties

MW = 198.2
C13H10O2
CAS 5690-03-9
>98% (TLC); NMR (Conforms)

Description

Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae (ref 1). Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA (ref 1). Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome (ref 2). Reverses ischemic preconditioning-induced cardioprotection in a mouse model (ref 3).

Contents

White powder. May be dissolved in DMSO (>25 mg/ml); Ethanol (>25 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. A Bedalov et al. Proc. Natl. Acad. Sci. USA 2001, 98:15113
2. R Biacsi et al. PLoS Genet. 2008, 4(3):e1000017
3. SM Nadtochiy et al. Cardiovasc. Res. 2011, 89:643

 
Chemical structure of Splitomicin.

Chemical structure of Splitomicin.