Active Motif,
Tools to analyze nuclear function,
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表观遗传 & 染色质

激活剂 / 抑制剂

表观遗传研究的小分子物质

Active Motif has a collection of small-molecule epigenetic modulators (activators and inhibitors) that target changes to DNA methylation and chromatin remodeling proteins, such as histones. These include targets to DNA Methyltransferases (DNMTs), Histone Acetyltransferases (HATs), Histone Deacetylases (HDACs), Histone Methyltransferases (HMTs), Histone Demethylases (HDMs) and a distinct set of chromatin readers, bromodomains. As epigenetic dysregulation is implicated in many diseases, these modulators represent important tools for researchers in their assay development and drug discovery initiatives.

A list of the available activators and inhibitors for epigenetic research is shown below. Please click on the small molecule name to view complete product information.

 
Name Appl. Format Cat No. Price  
2'-Deoxy-5-fluorocytidine DNMT Inhibitor 250 mg 14108 ¥5,437.50 Buy Now
50 mg 14109 ¥1,377.50 Buy Now
5-Aza-2’-deoxycytidine (Decitabine) DNMT Inhibitor 50 mg 14100 ¥6,017.50 Buy Now
10 mg 14101 ¥1,885 Buy Now
5-Azacytidine DNMT Inhibitor 250 mg 14102 ¥1,305 Buy Now
50 mg 14103 ¥580 Buy Now
6-Thioguanine DNMT Inhibitor 1 g 14126 ¥1,812.50 Buy Now
100 mg 14127 ¥507.50 Buy Now
AK-7 SIRT2 Inhibitor 25 mg 14054 ¥3,987.50 Buy Now
5 mg 14055 ¥1,160 Buy Now
Apicidin HDAC Inhibitor 5 mg 14040 ¥3,987.50 Buy Now
1 mg 14041 ¥1,232.50 Buy Now
Arecoline hydrobromide ACAT1 Inhibitor 1 g 14132 ¥1,232.50 Buy Now
250 mg 14133 ¥507.50 Buy Now
AS-8351 KDM5B Inhibitor 25 mg 14112 ¥3,987.50 Buy Now
5 mg 14113 ¥942.50 Buy Now
BIX-01294 G9a/GLP Inhibitor 25 mg 14072 ¥7,032.50 Buy Now
5 mg 14073 ¥2,175 Buy Now
BML-210 HDAC Inhibitor 25 mg 14048 ¥5,727.50 Buy Now
5 mg 14049 ¥1,595 Buy Now
BML-278 SIRT1 Activator 25 mg 14024 ¥4,277.50 Buy Now
5 mg 14025 ¥1,232.50 Buy Now
C646 p300/CBP Inhibitor 25 mg 14052 ¥6,235 Buy Now
5 mg 14053 ¥1,740 Buy Now
Chaetocin SU(VAR)3-9 Methyltransferase Inhibitor 200 µg 14051 ¥1,305 Buy Now
CI-994 HDAC Inhibitor 25 mg 14092 ¥4,205 Buy Now
5 mg 14093 ¥1,232.50 Buy Now
CPTH2 Gcn5P Inhibitor 25 mg 14094 ¥4,205 Buy Now
5 mg 14095 ¥1,232.50 Buy Now
CTPB p300 Activator 25 mg 14064 ¥6,235 Buy Now
5 mg 14065 ¥2,030 Buy Now
CUDC-101 HDAC and Receptor Tyrosine Kinase Inhibitor 25 mg 14060 ¥8,192.50 Buy Now
5 mg 14061 ¥2,247.50 Buy Now
Daminozide KDM2/KDM7 Inhibitor 250 mg 14058 ¥2,102.50 Buy Now
50 mg 14059 ¥725 Buy Now
DMOG PHD/JMJD2A Inhibitor 50 mg 14062 ¥4,277.50 Buy Now
10 mg 14063 ¥1,160 Buy Now
Embelin PCAF Inhibitor 50 mg 14118 ¥3,552.50 Buy Now
10 mg 14119 ¥797.50 Buy Now
EX-527 SIRT1 Inhibitor 25 mg 14028 ¥4,857.50 Buy Now
5 mg 14029 ¥1,305 Buy Now
FK-866 HCl Nampt Inhibitor 25 mg 14030 ¥4,350 Buy Now
5 mg 14031 ¥1,088 Buy Now
Garcinol p300/pCAF Inhbitor 50 mg 14076 ¥5,147.50 Buy Now
10 mg 14077 ¥1,377.50 Buy Now
GSK-J1 (cell impermeable) JMJD3/UTX Inhibitor 25 mg 14068 ¥4,857.50 Buy Now
5 mg 14069 ¥1,305 Buy Now
GSK-J4 (cell permeable) JMJD3/UTX Inhibitor 25 mg 14070 ¥4,857.50 Buy Now
5 mg 14071 ¥1,305 Buy Now
HPA (Hexyl-4-pentynoic acid) HDAC Inhibitor 50 mg 14034 ¥2,682.50 Buy Now
10 mg 14035 ¥725 Buy Now
IOX1 JMJD Family Inhibitor 25 mg 14056 ¥5,147.50 Buy Now
5 mg 14057 ¥1,377.50 Buy Now
JIB-04 JMJD Family Inhibitor 25 mg 14134 ¥3,262.50 Buy Now
5 mg 14135 ¥942.50 Buy Now
JQ1 (racemic) BET Bromodomain Inhibitor 25 mg 14066 ¥7,395 Buy Now
5 mg 14067 ¥2,102.50 Buy Now
Mithramycin A DNMT1 Inhibitor 5 mg 14128 ¥2,827.50 Buy Now
1 mg 14129 ¥725 Buy Now
ML-324 JMJD2 Inhibitor 25 mg 14078 ¥5,510 Buy Now
5 mg 14079 ¥1,450 Buy Now
Mocetinostat HDAC Inhibitor 25 mg 14136 ¥4,350 Buy Now
5 mg 14137 ¥1,232.50 Buy Now
MS-275 HDAC Inhibitor 25 mg 14042 ¥4,060 Buy Now
5 mg 14043 ¥1,305 Buy Now
NSC-663284 SETD8 Inhibitor 25 mg 14122 ¥5,437.50 Buy Now
5 mg 14123 ¥1,377.50 Buy Now
Panobinostat Class I and II HDAC Inhibitor 25 mg 14044 ¥4,060 Buy Now
5 mg 14045 ¥1,305 Buy Now
PBIT JARID1 Inhibitor 25 mg 14110 ¥3,480 Buy Now
5 mg 14111 ¥1,015 Buy Now
Piceatannol SIRT1 Activator 25 mg 14036 ¥3,480 Buy Now
5 mg 14037 ¥1,015 Buy Now
Resveratrol SIRT1 Activator 500 mg 14022 ¥3,480 Buy Now
100 mg 14023 ¥1,015 Buy Now
RG108 Non-nucleoside DNMT Inhibitor 25 mg 14104 ¥3,552.50 Buy Now
5 mg 14105 ¥942.50 Buy Now
Romidepsin HDAC Inhibitor 5 mg 14082 ¥2,900 Buy Now
HDAC Inhibitor 1 mg 14083 ¥3,625 Buy Now
RVX-208 BET Bromodomain Antagonist 25 mg 14090 ¥4,422.50 Buy Now
5 mg 14091 ¥1,305 Buy Now
Salermide SIRT Inhibitor 25 mg 14124 ¥3,987.50 Buy Now
5 mg 14125 ¥1,522.50 Buy Now
SGC707 PRMT3 Inhibitor 25 mg 14130 ¥4,423 Buy Now
5 mg 14131 ¥1,160 Buy Now
Sinefungin Methyltransferase Inhibitor 5 mg 14088 ¥3,697.50 Buy Now
1 mg 14089 ¥1,087.50 Buy Now
SirtAct SIRT1 Activator 25 mg 14080 ¥9,715 Buy Now
5 mg 14081 ¥2,320 Buy Now
Sirtinol SIRT Inhibitor 25 mg 14074 ¥7,032.50 Buy Now
5 mg 14075 ¥1,740 Buy Now
Sodium phenylbutyrate HDAC Inhibitor 5 g 14032 ¥1,305 Buy Now
HDAC Inhibitor 1 g 14033 ¥1,087.50 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 ¥3,625 Buy Now
5 mg 14087 ¥1,015 Buy Now
TC-E-5003 PRMT1 Inhibitor 50 mg 14099 ¥1,015 Buy Now
TM-2-51 HDAC8 Activator 50 mg 14096 ¥2,972.50 Buy Now
10 mg 14097 ¥870 Buy Now
Tranylcypromine hemisulfate LSD1/BHC110 Inhibitor 250 mg 14046 ¥2,320 Buy Now
50 mg 14047 ¥797.50 Buy Now
Triacetyl resveratrol SIRT Activator 250 mg 14116 ¥5,075 Buy Now
50 mg 14117 ¥2,030 Buy Now
Trichostatin A HDAC Inhibitor 5 mg 14038 ¥6,742.50 Buy Now
1 mg 14039 ¥2,175 Buy Now
Tubastatin A hydrochloride HDAC6 Inhibitor 25 mg 14084 ¥5,727.50 Buy Now
5 mg 14085 ¥1,667.50 Buy Now
UNC1999 EZH1 & EZH2 Inhibitor 25 mg 14114 ¥4,712.50 Buy Now
5 mg 14115 ¥1,595 Buy Now
UNC-2170 Methyl-lysine Binding Protein Inhibitor 25 mg 14120 ¥6,525 Buy Now
5 mg 14121 ¥1,595 Buy Now
Valproic Acid, sodium salt HDAC Inhibitor 5 g 14021 ¥580 Buy Now
Vorinostat (SAHA) HDAC Inhibitor 50 mg 14026 ¥5,075 Buy Now
10 mg 14027 ¥1,377.50 Buy Now
Zebularine DNMT Inhibitor 25 mg 14106 ¥3,697.50 Buy Now
5 mg 14107 ¥1,087.50 Buy Now